The Melburnian hip-hop artist announced on Facebook that he suffers from keratoconus, an inherited condition that causes degeneration of the eye's cornea.
The disease has already left 360 without vision in his right eye but now his left eye is deteriorating too.
"If you didn't know, I have a disease in my eyes called keratoconus … I am half blind," 360 (real name Matt Colwell) wrote on his Facebook page.
"I had a cornea transplant about six years ago … so I've been living with one good eye for ages and I'm totally cool with it, well I was … but now the disease has started to kick into my left eye … my vision gets worse by the day.
"My left eye is deteriorating rapidly … I need surgery ASAP or I will go blind."
The rapper also posted a picture of his eye after the cornea transplant.
But 360, who habitually wears a pair of dark-lensed sunglasses, hasn't lost his sense of humour during the ordeal.
"The positive is I don't need no excuse to wear sunnies indoors no more haha," he wrote, adding, "I could be the first Ray Charles of rap."
The 26-year-old took out Channel [V]'s Oz Artist of the Year in 2011, but is probably better known for dissing fellow Aussie hip hop artists Hilltop Hoods.
"The [song] nose bleed section made me want to break their nose," he once rapped in a freestyle contest.
Unfortunately, 360 is no stranger to health issues. In 2010 he had a go-karting accident which left him with a torn artery, lacerated pancreas and "ripped open" scrotum.